Predicted to be involved in transcription elongation by RNA polymerase I. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLR1F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR1F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR1F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:19,701,320–19,701,984 | 7.1 kb | Proximal (<10kb) | 43 | |
| chr7:19,705,748–19,706,013 | 3.0 kb | Proximal (<10kb) | 9 | |
| chr7:19,708,361–19,709,641 | 32 bp | At TSS Multiome | 869 | |
| chr7:19,713,776–19,713,961 | 4.7 kb | Proximal (<10kb) | 54 | |
| chr7:19,772,432–19,773,950 | 64.1 kb | Distal (>10kb) Multiome | 299 | |
| chr7:20,329,378–20,332,363 | 620.7 kb | Distal (>10kb) Multiome HiCAR | 815 | |
| chr7:20,653,525–20,654,195 | 944.8 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr7:20,700,321–20,701,121 | 991.7 kb | Distal (>10kb) Multiome HiCAR | 96 |
Genomic view of the POLR1F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.