This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for POLN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:2,008,507–2,010,125 | 232.9 kb | Distal (>10kb) Multiome | 1040 | |
| chr4:2,041,030–2,042,663 | 200.1 kb | Distal (>10kb) Multiome | 554 | |
| chr4:2,058,181–2,059,492 | 182.9 kb | Distal (>10kb) Multiome | 367 | |
| chr4:2,060,701–2,061,398 | 181.0 kb | Distal (>10kb) Multiome | 197 | |
| chr4:2,241,509–2,242,666 | 116 bp | At TSS Multiome | 783 | |
| chr4:2,261,141–2,263,069 | 20.2 kb | Distal (>10kb) Multiome | 806 | |
| chr4:2,401,939–2,402,479 | 160.1 kb | Distal (>10kb) Multiome | 317 | |
| chr4:2,413,008–2,413,630 | 171.3 kb | Distal (>10kb) Multiome | 564 | |
| chr4:2,417,912–2,419,213 | 176.7 kb | Distal (>10kb) Multiome | 628 | |
| chr4:2,462,245–2,463,183 | 220.6 kb | Distal (>10kb) Multiome | 643 | |
| chr4:2,468,399–2,469,652 | 226.9 kb | Distal (>10kb) Multiome | 858 | |
| chr4:2,535,307–2,537,785 | 294.3 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the POLN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.