The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for POLI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:54,223,556–54,225,199 | 44.9 kb | Distal (>10kb) Multiome | 810 | |
| chr18:54,235,612–54,236,484 | 33.5 kb | Distal (>10kb) Multiome | 178 | |
| chr18:54,246,611–54,248,045 | 22.3 kb | Distal (>10kb) Multiome | 501 | |
| chr18:54,268,849–54,270,571 | 92 bp | At TSS Multiome | 936 | |
| chr18:54,357,058–54,358,694 | 88.3 kb | Distal (>10kb) Multiome | 739 | |
| chr18:54,480,384–54,481,350 | 211.3 kb | Distal (>10kb) Multiome | 108 | |
| chr18:54,528,914–54,529,969 | 259.9 kb | Distal (>10kb) Multiome | 181 | |
| chr18:54,531,114–54,532,495 | 262.0 kb | Distal (>10kb) Multiome | 125 |
Genomic view of the POLI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.