DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for POLE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,585,877–49,587,282 | 101.7 kb | Distal (>10kb) Multiome | 966 | |
| chr14:49,598,179–49,599,418 | 89.4 kb | Distal (>10kb) Multiome | 967 | |
| chr14:49,620,144–49,621,897 | 67.5 kb | Distal (>10kb) Multiome | 930 | |
| chr14:49,633,485–49,635,896 | 53.8 kb | Distal (>10kb) Multiome | 1040 | |
| chr14:49,687,569–49,688,718 | 63 bp | At TSS Multiome | 843 | |
| chr14:49,692,914–49,693,633 | 5.1 kb | Proximal (<10kb) Multiome | 764 | |
| chr14:49,767,430–49,769,102 | 79.8 kb | Distal (>10kb) Multiome | 899 | |
| chr14:49,852,270–49,853,410 | 164.6 kb | Distal (>10kb) Multiome | 813 | |
| chr14:49,853,662–49,854,089 | 165.8 kb | Distal (>10kb) Multiome | 439 | |
| chr14:49,861,592–49,863,464 | 174.7 kb | Distal (>10kb) Multiome | 1038 | |
| chr14:49,867,745–49,868,682 | 180.0 kb | Distal (>10kb) Multiome | 699 | |
| chr14:49,892,363–49,894,019 | 204.8 kb | Distal (>10kb) Multiome | 981 |
Genomic view of the POLE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.