The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for POGK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POGK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POGK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:166,838,839–166,841,323 | 1.4 kb | Proximal (<10kb) Multiome | 1080 | |
| chr1:166,875,665–166,876,831 | 36.9 kb | Distal (>10kb) Multiome | 947 | |
| chr1:166,883,947–166,884,647 | 45.0 kb | Distal (>10kb) Multiome | 218 | |
| chr1:166,920,313–166,921,576 | 81.5 kb | Distal (>10kb) Multiome | 206 | |
| chr1:166,975,212–166,976,080 | 136.2 kb | Distal (>10kb) Multiome | 470 | |
| chr1:167,066,432–167,066,980 | 227.3 kb | Distal (>10kb) Multiome | 430 | |
| chr1:167,121,335–167,122,028 | 282.2 kb | Distal (>10kb) Multiome | 238 |
Genomic view of the POGK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.