POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for POC1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POC1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POC1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:51,868,646–51,869,606 | 285.4 kb | Distal (>10kb) Multiome | 50 | |
| chr3:51,941,340–51,942,909 | 212.3 kb | Distal (>10kb) Multiome | 890 | |
| chr3:51,955,723–51,956,827 | 197.9 kb | Distal (>10kb) Multiome | 289 | |
| chr3:51,967,071–51,968,598 | 186.9 kb | Distal (>10kb) Multiome | 581 | |
| chr3:51,973,571–51,975,404 | 180.4 kb | Distal (>10kb) Multiome | 886 | |
| chr3:51,982,506–51,983,633 | 171.2 kb | Distal (>10kb) Multiome | 933 | |
| chr3:51,990,597–51,991,772 | 163.4 kb | Distal (>10kb) Multiome | 145 | |
| chr3:51,995,468–51,996,121 | 158.5 kb | Distal (>10kb) Multiome HiCAR | 938 | |
| chr3:52,001,516–52,001,992 | 152.7 kb | Distal (>10kb) Multiome HiCAR | 448 | |
| chr3:52,055,881–52,058,048 | 96.9 kb | Distal (>10kb) Multiome | 937 | |
| chr3:52,128,194–52,128,700 | 26.0 kb | Distal (>10kb) Multiome | 376 | |
| chr3:52,144,346–52,144,571 | 9.8 kb | Proximal (<10kb) | 238 | |
| chr3:52,153,766–52,155,196 | 253 bp | At TSS Multiome | 896 | |
| chr3:52,197,554–52,198,856 | 43.7 kb | Distal (>10kb) Multiome | 731 | |
| chr3:52,238,767–52,239,716 | 84.8 kb | Distal (>10kb) Multiome | 763 | |
| chr3:52,245,446–52,246,450 | 91.6 kb | Distal (>10kb) Multiome | 553 | |
| chr3:52,277,664–52,279,184 | 124.3 kb | Distal (>10kb) Multiome | 844 | |
| chr3:52,287,499–52,288,336 | 133.5 kb | Distal (>10kb) Multiome | 778 | |
| chr3:52,409,430–52,411,187 | 255.9 kb | Distal (>10kb) Multiome | 813 | |
| chr3:52,444,941–52,445,411 | 290.7 kb | Distal (>10kb) Multiome | 426 |
Genomic view of the POC1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.