Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus and nucleoplasm. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PNO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PNO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PNO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:67,880,031–67,880,830 | 277.4 kb | Distal (>10kb) Multiome | 160 | |
| chr2:67,895,074–67,895,942 | 262.4 kb | Distal (>10kb) Multiome | 256 | |
| chr2:67,919,380–67,920,561 | 238.0 kb | Distal (>10kb) Multiome | 90 | |
| chr2:68,062,503–68,063,411 | 94.9 kb | Distal (>10kb) Multiome | 755 | |
| chr2:68,120,653–68,121,790 | 36.7 kb | Distal (>10kb) Multiome | 486 | |
| chr2:68,156,957–68,158,339 | 99 bp | At TSS Multiome | 970 | |
| chr2:68,250,908–68,253,446 | 94.8 kb | Distal (>10kb) Multiome | 1015 | |
| chr2:68,318,412–68,319,996 | 161.7 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the PNO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.