PNISR

PNN interacting serine and arginine rich protein | DKFZp564B0769, FLJ14752, SRrp130, bA98I9.2, C6orf111, SFRS18

Enables RNA binding activity. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7 DE-7.2

Biological processes 5 terms

RNA binding (GO:0003723)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nuclear speck (GO:0016607)presynaptic active zone (GO:0048786)

Expression (TPM)

TFs regulating PNISR 0 TFs

Transcription factors with Perturb-seq knockdown data for PNISR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PNISR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PNISR

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PNISR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:99,219,557–99,220,312	205.3 kb	Distal (>10kb) Multiome	105
chr6:99,348,770–99,350,367	75.5 kb	Distal (>10kb) Multiome	615
chr6:99,393,480–99,394,529	31.3 kb	Distal (>10kb) Multiome	782
chr6:99,424,727–99,426,355	163 bp	At TSS Multiome	975
chr6:99,435,060–99,435,190	9.8 kb	Proximal (<10kb)	53
chr6:99,514,702–99,516,390	90.2 kb	Distal (>10kb) Multiome	945
chr6:99,520,676–99,522,033	95.8 kb	Distal (>10kb) Multiome	822
chr6:99,567,957–99,569,279	143.4 kb	Distal (>10kb) Multiome	1064
chr6:99,588,272–99,589,608	163.6 kb	Distal (>10kb) Multiome	545
chr6:99,602,753–99,604,086	178.4 kb	Distal (>10kb) Multiome	376
chr6:99,612,582–99,615,086	188.4 kb	Distal (>10kb) Multiome	533
chr6:99,618,513–99,619,470	193.6 kb	Distal (>10kb) Multiome	225

Genome Browser

Genomic view of the PNISR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.