Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PMM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PMM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PMM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:41,301,155–41,301,870 | 288.3 kb | Distal (>10kb) Multiome | 658 | |
| chr22:41,380,458–41,382,737 | 208.1 kb | Distal (>10kb) Multiome | 925 | |
| chr22:41,413,486–41,414,305 | 175.9 kb | Distal (>10kb) Multiome | 832 | |
| chr22:41,444,084–41,445,743 | 145.3 kb | Distal (>10kb) Multiome | 607 | |
| chr22:41,446,165–41,449,007 | 142.9 kb | Distal (>10kb) Multiome | 1188 | |
| chr22:41,468,341–41,469,602 | 120.9 kb | Distal (>10kb) Multiome | 920 | |
| chr22:41,512,659–41,513,151 | 76.8 kb | Distal (>10kb) Multiome | 354 | |
| chr22:41,543,855–41,544,782 | 45.3 kb | Distal (>10kb) Multiome | 755 | |
| chr22:41,589,188–41,590,530 | 173 bp | At TSS Multiome | 758 | |
| chr22:41,597,374–41,597,573 | 7.6 kb | Proximal (<10kb) | 317 | |
| chr22:41,620,173–41,622,049 | 31.3 kb | Distal (>10kb) Multiome | 880 | |
| chr22:41,666,496–41,667,405 | 77.1 kb | Distal (>10kb) Multiome | 725 | |
| chr22:41,697,169–41,697,792 | 107.5 kb | Distal (>10kb) Multiome | 464 | |
| chr22:41,800,274–41,801,345 | 210.8 kb | Distal (>10kb) Multiome | 816 | |
| chr22:41,832,291–41,834,215 | 243.1 kb | Distal (>10kb) Multiome | 1023 | |
| chr22:41,845,927–41,846,489 | 256.3 kb | Distal (>10kb) Multiome | 271 |
Genomic view of the PMM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.