Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PLXNB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLXNB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLXNB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:50,030,288–50,030,739 | 277.2 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,169,918–50,170,446 | 137.4 kb | Distal (>10kb) Multiome | 245 | |
| chr22:50,184,288–50,186,776 | 121.8 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 106.6 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 62.5 kb | Distal (>10kb) Multiome | 868 | |
| chr22:50,250,480–50,251,917 | 56.2 kb | Distal (>10kb) Multiome | 683 | |
| chr22:50,261,070–50,261,932 | 46.0 kb | Distal (>10kb) Multiome | 512 | |
| chr22:50,267,469–50,268,208 | 39.9 kb | Distal (>10kb) Multiome | 196 | |
| chr22:50,271,717–50,272,193 | 35.7 kb | Distal (>10kb) Multiome | 331 | |
| chr22:50,299,702–50,300,750 | 7.2 kb | Proximal (<10kb) Multiome | 250 | |
| chr22:50,307,140–50,307,760 | 28 bp | At TSS Multiome | 392 | |
| chr22:50,326,615–50,327,631 | 19.5 kb | Distal (>10kb) Multiome | 754 | |
| chr22:50,342,153–50,342,608 | 34.9 kb | Distal (>10kb) Multiome | 553 | |
| chr22:50,342,772–50,343,603 | 35.6 kb | Distal (>10kb) Multiome | 573 | |
| chr22:50,474,348–50,475,571 | 167.5 kb | Distal (>10kb) Multiome | 487 | |
| chr22:50,481,062–50,482,150 | 173.9 kb | Distal (>10kb) Multiome | 387 | |
| chr22:50,506,343–50,508,710 | 200.4 kb | Distal (>10kb) Multiome | 856 | |
| chr22:50,524,965–50,527,480 | 219.5 kb | Distal (>10kb) Multiome | 1031 | |
| chr22:50,529,065–50,532,692 | 223.3 kb | Distal (>10kb) Multiome | 745 | |
| chr22:50,562,609–50,563,508 | 255.3 kb | Distal (>10kb) Multiome | 680 | |
| chr22:50,582,134–50,583,431 | 275.3 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the PLXNB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.