PLSCR3
phospholipid scramblase 3

Enables calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including apoptotic process; mitochondrial membrane organization; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 34 terms
apoptotic process (GO:0006915)apoptotic process (GO:0006915)apoptotic process (GO:0006915)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)calcium-dependent protein binding (GO:0048306)cellular response to lipopolysaccharide (GO:0071222)cytosol (GO:0005829)lead ion binding (GO:0032791)magnesium ion binding (GO:0000287)mercury ion binding (GO:0045340)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial membrane (GO:0031966)mitochondrial membrane organization (GO:0007006)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleus (GO:0005634)nucleus (GO:0005634)phospholipid scramblase activity (GO:0017128)phospholipid scramblase activity (GO:0017128)phospholipid scramblase activity (GO:0017128)phospholipid scramblase activity (GO:0017128)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane phospholipid scrambling (GO:0017121)plasma membrane phospholipid scrambling (GO:0017121)plasma membrane phospholipid scrambling (GO:0017121)protein binding (GO:0005515)regulation of apoptotic process (GO:0042981)regulation of release of cytochrome c from mitochondria (GO:0090199)regulation of release of cytochrome c from mitochondria (GO:0090199)
Expression (TPM)
PLSCR3 — as a Regulated Gene

TFs regulating PLSCR3 0 TFs

Transcription factors with Perturb-seq knockdown data for PLSCR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLSCR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PLSCR3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLSCR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,132,532–7,133,109 261.7 kb Distal (>10kb) Multiome 312
chr17:7,177,263–7,177,909 217.0 kb Distal (>10kb) Multiome 453
chr17:7,204,820–7,205,551 189.4 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 186.3 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 180.1 kb Distal (>10kb) Multiome 737
chr17:7,219,603–7,220,515 174.6 kb Distal (>10kb) Multiome 793
chr17:7,233,847–7,235,210 160.0 kb Distal (>10kb) Multiome 1020
chr17:7,237,531–7,238,757 156.6 kb Distal (>10kb) Multiome 502
chr17:7,238,867–7,240,155 154.9 kb Distal (>10kb) Multiome 783
chr17:7,241,494–7,243,462 151.5 kb Distal (>10kb) Multiome 1037
chr17:7,251,263–7,252,962 142.4 kb Distal (>10kb) Multiome 985
chr17:7,260,746–7,263,748 131.9 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 112.9 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 99.8 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 98.0 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 87.2 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 79.2 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 65.1 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 44.3 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 42.5 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 38.3 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 10.3 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 126 bp At TSS Multiome 744
chr17:7,403,290–7,405,695 9.8 kb Proximal (<10kb) Multiome 838
chr17:7,435,167–7,437,681 42.6 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 43.8 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 46.2 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 51.0 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 61.1 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 85.0 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 89.9 kb Distal (>10kb) Multiome 1156
chr17:7,548,693–7,549,285 154.5 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 167.4 kb Distal (>10kb) Multiome HiCAR 759
chr17:7,572,039–7,574,418 179.3 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 184.9 kb Distal (>10kb) Multiome 844
chr17:7,583,063–7,584,547 189.2 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 195.6 kb Distal (>10kb) Multiome 319
chr17:7,614,065–7,615,780 220.6 kb Distal (>10kb) Multiome 708
chr17:7,627,090–7,628,247 233.3 kb Distal (>10kb) Multiome 712
chr17:7,650,010–7,652,127 256.2 kb Distal (>10kb) Multiome 467
chr17:7,685,876–7,686,907 291.8 kb Distal (>10kb) Multiome 765
chr17:7,687,214–7,687,777 293.0 kb Distal (>10kb) Multiome 710
chr17:7,687,867–7,688,863 293.8 kb Distal (>10kb) Multiome 700

Genome Browser

Genomic view of the PLSCR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,122,532 – 7,698,863
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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