This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for PLRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:154,489,612–154,492,716 | 58.4 kb | Distal (>10kb) Multiome | 547 | |
| chr4:154,548,823–154,550,849 | 30 bp | At TSS Multiome | 633 | |
| chr4:154,552,193–154,552,554 | 1.8 kb | Proximal (<10kb) | 225 | |
| chr4:154,559,283–154,559,738 | 8.9 kb | Proximal (<10kb) | 266 | |
| chr4:154,626,265–154,627,724 | 76.6 kb | Distal (>10kb) Multiome HiCAR | 532 | |
| chr4:154,720,234–154,721,419 | 170.5 kb | Distal (>10kb) Multiome | 149 | |
| chr4:154,741,135–154,745,616 | 193.6 kb | Distal (>10kb) Multiome HiCAR | 524 | |
| chr4:155,376,323–155,377,313 | 826.5 kb | Distal (>10kb) Multiome HiCAR | 467 |
Genomic view of the PLRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.