The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for PLIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:17,134,290–17,135,974 | 1992.4 kb | Distal (>10kb) Multiome HiCAR | 810 | |
| chr9:19,048,607–19,050,217 | 78.2 kb | Distal (>10kb) Multiome | 993 | |
| chr9:19,102,191–19,103,414 | 24.5 kb | Distal (>10kb) Multiome | 770 | |
| chr9:19,126,915–19,128,564 | 64 bp | At TSS Multiome | 808 | |
| chr9:19,128,771–19,129,257 | 1.3 kb | Proximal (<10kb) | 196 | |
| chr9:19,129,756–19,129,997 | 2.3 kb | Proximal (<10kb) | 209 | |
| chr9:19,130,146–19,130,935 | 2.7 kb | Proximal (<10kb) | 147 | |
| chr9:19,201,888–19,203,074 | 74.9 kb | Distal (>10kb) Multiome | 569 | |
| chr9:19,229,553–19,231,458 | 103.1 kb | Distal (>10kb) Multiome | 973 | |
| chr9:19,379,591–19,380,878 | 252.8 kb | Distal (>10kb) Multiome | 1052 | |
| chr9:19,408,145–19,409,950 | 281.4 kb | Distal (>10kb) Multiome | 773 | |
| chr9:19,446,288–19,446,838 | 319.2 kb | Distal (>10kb) Multiome HiCAR | 110 |
Genomic view of the PLIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.