Predicted to be located in cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,240,431–67,242,037 | 292.0 kb | Distal (>10kb) Multiome | 924 | |
| chr14:67,359,034–67,360,833 | 173.3 kb | Distal (>10kb) Multiome | 891 | |
| chr14:67,427,006–67,427,629 | 105.9 kb | Distal (>10kb) Multiome HiCAR | 288 | |
| chr14:67,514,900–67,515,814 | 17.9 kb | Distal (>10kb) Multiome | 411 | |
| chr14:67,526,653–67,527,074 | 6.2 kb | Proximal (<10kb) | 216 | |
| chr14:67,532,784–67,533,987 | 3 bp | At TSS Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 8.7 kb | Proximal (<10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 66.9 kb | Distal (>10kb) Multiome | 746 | |
| chr14:67,619,336–67,620,756 | 86.5 kb | Distal (>10kb) Multiome | 794 | |
| chr14:67,674,148–67,675,415 | 141.5 kb | Distal (>10kb) Multiome | 840 | |
| chr14:67,694,763–67,695,985 | 161.6 kb | Distal (>10kb) Multiome | 742 | |
| chr14:67,729,052–67,729,527 | 196.0 kb | Distal (>10kb) Multiome | 407 | |
| chr14:67,816,043–67,817,024 | 283.3 kb | Distal (>10kb) Multiome | 712 | |
| chr14:67,819,625–67,820,281 | 286.5 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the PLEKHH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.