Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in cell junction and centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHG6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHG6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHG6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,056,451–6,057,152 | 254.0 kb | Distal (>10kb) Multiome | 147 | |
| chr12:6,124,068–6,125,228 | 186.0 kb | Distal (>10kb) Multiome | 240 | |
| chr12:6,199,391–6,201,130 | 110.4 kb | Distal (>10kb) Multiome | 481 | |
| chr12:6,214,773–6,215,509 | 95.4 kb | Distal (>10kb) Multiome | 158 | |
| chr12:6,278,466–6,279,375 | 31.9 kb | Distal (>10kb) Multiome | 655 | |
| chr12:6,310,091–6,311,512 | 3 bp | At TSS Multiome | 645 | |
| chr12:6,312,484–6,312,912 | 1.8 kb | Proximal (<10kb) | 234 | |
| chr12:6,322,926–6,323,961 | 12.7 kb | Distal (>10kb) Multiome HiCAR | 536 | |
| chr12:6,329,238–6,330,028 | 18.9 kb | Distal (>10kb) Multiome | 135 | |
| chr12:6,335,766–6,337,493 | 26.0 kb | Distal (>10kb) Multiome | 962 | |
| chr12:6,341,619–6,342,234 | 31.5 kb | Distal (>10kb) Multiome | 657 | |
| chr12:6,363,292–6,364,138 | 52.9 kb | Distal (>10kb) Multiome | 718 | |
| chr12:6,370,899–6,371,535 | 60.6 kb | Distal (>10kb) Multiome | 572 | |
| chr12:6,375,204–6,377,302 | 64.8 kb | Distal (>10kb) Multiome | 601 | |
| chr12:6,383,790–6,384,442 | 73.4 kb | Distal (>10kb) Multiome | 812 | |
| chr12:6,451,305–6,451,838 | 140.7 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 160.2 kb | Distal (>10kb) Multiome | 930 | |
| chr12:6,492,998–6,494,331 | 182.6 kb | Distal (>10kb) Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 223.6 kb | Distal (>10kb) Multiome | 1131 | |
| chr12:6,539,914–6,540,883 | 230.0 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 243.6 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 245.4 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 257.7 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 296.8 kb | Distal (>10kb) Multiome | 774 |
Genomic view of the PLEKHG6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.