This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for PLEKHG4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHG4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHG4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:52,897–54,263 | 38.4 kb | Distal (>10kb) Multiome | 379 | |
| chr5:82,168–82,453 | 9.7 kb | Proximal (<10kb) | 180 | |
| chr5:91,673–92,358 | 87 bp | At TSS Multiome | 279 | |
| chr5:188,610–189,107 | 96.6 kb | Distal (>10kb) Multiome | 472 | |
| chr5:217,613–219,286 | 126.0 kb | Distal (>10kb) Multiome | 692 | |
| chr5:271,018–272,107 | 179.3 kb | Distal (>10kb) Multiome | 866 | |
| chr5:320,742–322,619 | 229.4 kb | Distal (>10kb) Multiome | 441 |
Genomic view of the PLEKHG4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.