Enables actin binding activity. Involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:64,465,087–64,466,161 | 239.0 kb | Distal (>10kb) Multiome | 490 | |
| chr14:64,502,980–64,505,716 | 200.6 kb | Distal (>10kb) Multiome | 1045 | |
| chr14:64,508,924–64,509,409 | 195.2 kb | Distal (>10kb) Multiome | 117 | |
| chr14:64,539,520–64,541,644 | 164.0 kb | Distal (>10kb) Multiome | 722 | |
| chr14:64,549,785–64,550,422 | 154.4 kb | Distal (>10kb) Multiome | 234 | |
| chr14:64,645,238–64,645,989 | 58.8 kb | Distal (>10kb) Multiome | 252 | |
| chr14:64,657,975–64,659,082 | 45.8 kb | Distal (>10kb) Multiome | 104 | |
| chr14:64,688,830–64,689,973 | 15.3 kb | Distal (>10kb) Multiome | 173 | |
| chr14:64,702,676–64,705,752 | 11 bp | At TSS Multiome | 771 | |
| chr14:64,706,578–64,707,299 | 2.2 kb | Proximal (<10kb) | 337 | |
| chr14:64,708,103–64,708,910 | 4.0 kb | Proximal (<10kb) Multiome | 355 | |
| chr14:64,715,550–64,715,810 | at TSS | At TSS | 107 | |
| chr14:64,715,917–64,716,184 | 215 bp | At TSS | 83 | |
| chr14:64,716,808–64,717,090 | 1.1 kb | Proximal (<10kb) | 197 | |
| chr14:64,718,421–64,718,816 | 2.7 kb | Proximal (<10kb) | 19 | |
| chr14:64,764,629–64,765,271 | 60.5 kb | Distal (>10kb) Multiome HiCAR | 313 | |
| chr14:64,823,107–64,823,713 | 119.0 kb | Distal (>10kb) Multiome | 316 | |
| chr14:64,879,129–64,880,883 | 176.0 kb | Distal (>10kb) Multiome | 485 | |
| chr14:64,914,197–64,914,885 | 210.0 kb | Distal (>10kb) Multiome | 741 | |
| chr14:64,971,572–64,972,862 | 267.9 kb | Distal (>10kb) Multiome | 360 | |
| chr14:64,986,666–64,987,558 | 282.6 kb | Distal (>10kb) Multiome | 890 |
Genomic view of the PLEKHG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.