Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:130,836,282–130,837,627 | 268.5 kb | Distal (>10kb) Multiome | 339 | |
| chr2:130,963,257–130,964,855 | 140.6 kb | Distal (>10kb) Multiome | 287 | |
| chr2:130,966,174–130,967,560 | 138.5 kb | Distal (>10kb) Multiome | 143 | |
| chr2:131,034,253–131,036,833 | 70.3 kb | Distal (>10kb) Multiome | 226 | |
| chr2:131,076,813–131,077,478 | 28.3 kb | Distal (>10kb) Multiome | 139 | |
| chr2:131,092,844–131,094,042 | 12.0 kb | Distal (>10kb) Multiome | 934 | |
| chr2:131,104,647–131,106,790 | 58 bp | At TSS Multiome | 914 | |
| chr2:131,153,640–131,154,672 | 48.9 kb | Distal (>10kb) Multiome | 397 |
Genomic view of the PLEKHB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.