Enables fibronectin binding activity; laminin binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in positive regulation of cell-matrix adhesion. Located in cytoplasm and membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:38,734,447–38,735,152 | 167.0 kb | Distal (>10kb) Multiome | 738 | |
| chr8:38,756,730–38,757,722 | 144.7 kb | Distal (>10kb) Multiome | 535 | |
| chr8:38,786,808–38,788,320 | 114.6 kb | Distal (>10kb) Multiome | 620 | |
| chr8:38,899,958–38,902,158 | 499 bp | At TSS Multiome | 565 | |
| chr8:38,973,978–38,975,173 | 72.8 kb | Distal (>10kb) Multiome | 205 | |
| chr8:38,995,870–38,997,751 | 94.9 kb | Distal (>10kb) Multiome | 913 |
Genomic view of the PLEKHA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.