PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for PLCH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLCH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLCH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:155,362,992–155,363,934 | 381.7 kb | Distal (>10kb) Multiome HiCAR | 308 | |
| chr3:155,744,096–155,745,472 | 818 bp | At TSS Multiome | 726 | |
| chr3:155,745,739–155,746,446 | 1.2 kb | Proximal (<10kb) Multiome | 309 | |
| chr3:155,748,405–155,748,776 | 3.3 kb | Proximal (<10kb) | 22 | |
| chr3:155,805,529–155,806,648 | 61.2 kb | Distal (>10kb) Multiome | 810 | |
| chr3:155,853,753–155,855,235 | 109.5 kb | Distal (>10kb) Multiome | 1097 | |
| chr3:155,869,838–155,871,872 | 125.4 kb | Distal (>10kb) Multiome | 931 | |
| chr3:155,980,533–155,981,958 | 236.0 kb | Distal (>10kb) Multiome | 149 |
Genomic view of the PLCH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.