Transcription factors with Perturb-seq knockdown data for PLCG1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLCG1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLCG1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:40,949,667–40,950,138 | 188.2 kb | Distal (>10kb) Multiome | 26 | |
| chr20:40,990,562–40,991,029 | 147.3 kb | Distal (>10kb) Multiome | 486 | |
| chr20:41,028,014–41,029,610 | 109.3 kb | Distal (>10kb) Multiome | 977 | |
| chr20:41,135,300–41,135,808 | 2.6 kb | Proximal (<10kb) Multiome | 451 | |
| chr20:41,136,345–41,138,443 | 757 bp | At TSS Multiome | 1007 | |
| chr20:41,249,859–41,250,320 | 112.1 kb | Distal (>10kb) Multiome | 183 | |
| chr20:41,316,979–41,318,388 | 179.8 kb | Distal (>10kb) Multiome | 894 | |
| chr20:41,339,588–41,341,431 | 202.7 kb | Distal (>10kb) Multiome | 904 | |
| chr20:41,365,890–41,367,375 | 228.8 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the PLCG1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.