This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for PLCD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLCD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLCD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,859,865–37,862,804 | 169.1 kb | Distal (>10kb) Multiome | 1005 | |
| chr3:37,986,618–37,987,603 | 42.5 kb | Distal (>10kb) Multiome | 525 | |
| chr3:37,993,686–37,994,594 | 35.4 kb | Distal (>10kb) Multiome | 519 | |
| chr3:37,998,336–37,999,630 | 30.5 kb | Distal (>10kb) Multiome | 510 | |
| chr3:38,001,564–38,001,791 | 7.0 kb | Proximal (<10kb) | 71 | |
| chr3:38,003,084–38,004,028 | 26.1 kb | Distal (>10kb) Multiome | 352 | |
| chr3:38,004,488–38,004,672 | 4.1 kb | Proximal (<10kb) | 400 | |
| chr3:38,023,878–38,025,927 | 4.8 kb | Proximal (<10kb) Multiome | 762 | |
| chr3:38,028,710–38,030,184 | 33 bp | At TSS Multiome | 378 | |
| chr3:38,039,093–38,039,944 | 9.7 kb | Proximal (<10kb) Multiome | 357 | |
| chr3:38,136,419–38,139,307 | 109.1 kb | Distal (>10kb) Multiome HiCAR | 989 | |
| chr3:38,164,619–38,166,160 | 135.6 kb | Distal (>10kb) Multiome | 1040 | |
| chr3:38,649,012–38,650,212 | 620.0 kb | Distal (>10kb) Multiome HiCAR | 437 | |
| chr3:38,651,034–38,651,663 | 621.7 kb | Distal (>10kb) Multiome HiCAR | 351 |
Genomic view of the PLCD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.