Transcription factors with Perturb-seq knockdown data for PLAC8L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAC8L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAC8L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:145,834,746–145,836,489 | 270.1 kb | Distal (>10kb) Multiome | 918 | |
| chr5:145,855,918–145,856,897 | 249.1 kb | Distal (>10kb) Multiome | 434 | |
| chr5:145,936,249–145,937,190 | 168.9 kb | Distal (>10kb) Multiome | 653 | |
| chr5:146,026,278–146,026,799 | 79.1 kb | Distal (>10kb) Multiome | 138 | |
| chr5:146,073,032–146,074,223 | 31.9 kb | Distal (>10kb) Multiome | 179 | |
| chr5:146,182,165–146,183,510 | 77.2 kb | Distal (>10kb) Multiome | 994 | |
| chr5:146,202,953–146,204,079 | 97.9 kb | Distal (>10kb) Multiome | 825 | |
| chr5:146,338,076–146,339,360 | 233.3 kb | Distal (>10kb) Multiome | 195 | |
| chr5:146,344,641–146,346,403 | 239.4 kb | Distal (>10kb) Multiome | 236 |
Genomic view of the PLAC8L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.