This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PKIB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PKIB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PKIB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:122,399,121–122,400,368 | 82.5 kb | Distal (>10kb) Multiome | 922 | |
| chr6:122,471,228–122,472,247 | 10.2 kb | Distal (>10kb) Multiome | 823 | |
| chr6:122,481,899–122,482,402 | at TSS | At TSS | 86 | |
| chr6:122,482,580–122,482,999 | 502 bp | At TSS | 15 | |
| chr6:122,484,795–122,485,155 | 2.7 kb | Proximal (<10kb) | 110 | |
| chr6:122,492,005–122,492,202 | 9.9 kb | Proximal (<10kb) | 144 | |
| chr6:122,609,513–122,611,433 | 128.4 kb | Distal (>10kb) Multiome | 891 | |
| chr6:122,755,674–122,756,269 | 274.0 kb | Distal (>10kb) Multiome | 186 | |
| chr6:122,779,040–122,780,034 | 297.4 kb | Distal (>10kb) Multiome | 189 |
Genomic view of the PKIB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.