PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PITPNM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PITPNM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PITPNM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,895,832–122,896,391 | 255.0 kb | Distal (>10kb) Multiome | 774 | |
| chr12:122,965,963–122,966,953 | 184.5 kb | Distal (>10kb) Multiome | 576 | |
| chr12:122,974,115–122,975,704 | 176.2 kb | Distal (>10kb) Multiome | 889 | |
| chr12:122,980,138–122,981,155 | 170.4 kb | Distal (>10kb) Multiome | 817 | |
| chr12:123,049,639–123,050,104 | 101.3 kb | Distal (>10kb) Multiome | 45 | |
| chr12:123,150,285–123,151,740 | 29 bp | At TSS Multiome | 487 | |
| chr12:123,232,511–123,233,923 | 82.1 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:123,269,375–123,269,864 | 118.6 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 120.2 kb | Distal (>10kb) Multiome | 488 | |
| chr12:123,363,804–123,365,980 | 214.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr12:123,383,367–123,384,963 | 232.8 kb | Distal (>10kb) Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 237.8 kb | Distal (>10kb) Multiome | 446 | |
| chr12:123,436,072–123,436,895 | 285.6 kb | Distal (>10kb) Multiome | 742 |
Genomic view of the PITPNM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.