PINK1

PINK1

PTEN induced kinase 1 | BRPK, PARK6

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

Developmental clusters: GC2

Biological processes 141 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)C3HC4-type RING finger domain binding (GO:0055131)Lewy body (GO:0097413)TORC2 signaling (GO:0038203)astrocyte projection (GO:0097449)autophagy of mitochondrion (GO:0000422)autophagy of mitochondrion (GO:0000422)axon (GO:0030424)cell body (GO:0044297)cellular response to hydrogen sulfide (GO:1904881)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to toxic substance (GO:0097237)cellular response to toxic substance (GO:0097237)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)growth cone (GO:0030426)hemopoiesis (GO:0030097)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)kinase activity (GO:0016301)kinase activity (GO:0016301)kinase activity (GO:0016301)kinase binding (GO:0019900)macroautophagy (GO:0016236)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)maintenance of protein location in mitochondrion (GO:0072656)membrane (GO:0016020)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)mitochondrion to lysosome vesicle-mediated transport (GO:0099074)mitophagy (GO:0000423)mitophagy (GO:0000423)mitophagy (GO:0000423)negative regulation of JNK cascade (GO:0046329)negative regulation of apoptotic process (GO:0043066)negative regulation of autophagosome assembly (GO:1902902)negative regulation of gene expression (GO:0010629)negative regulation of gene expression (GO:0010629)negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway (GO:1903384)negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway (GO:1903384)negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway (GO:1903298)negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide (GO:1903751)negative regulation of macroautophagy (GO:0016242)negative regulation of mitochondrial fission (GO:0090258)negative regulation of mitophagy (GO:1901525)negative regulation of neuron apoptotic process (GO:0043524)negative regulation of neuron apoptotic process (GO:0043524)negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903377)negative regulation of reactive oxygen species metabolic process (GO:2000378)nucleus (GO:0005634)peptidase activator activity (GO:0016504)perinuclear region of cytoplasm (GO:0048471)positive regulation of ATP biosynthetic process (GO:2001171)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of cell migration (GO:0030335)positive regulation of cristae formation (GO:1903852)positive regulation of free ubiquitin chain polymerization (GO:1904544)positive regulation of macroautophagy (GO:0016239)positive regulation of mitochondrial electron transport, NADH to ubiquinone (GO:1902958)positive regulation of mitochondrial fission (GO:0090141)positive regulation of mitochondrial fission (GO:0090141)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of protein localization to mitochondrion (GO:1903749)positive regulation of protein ubiquitination (GO:0031398)positive regulation of release of cytochrome c from mitochondria (GO:0090200)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of translation (GO:0045727)positive regulation of type 2 mitophagy (GO:1905091)protease binding (GO:0002020)protease binding (GO:0002020)protein binding (GO:0005515)protein kinase B binding (GO:0043422)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein localization to mitochondrion (GO:0070585)protein phosphorylation (GO:0006468)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein ubiquitination (GO:0016567)protein-containing complex binding (GO:0044877)regulation of apoptotic process (GO:0042981)regulation of autophagy of mitochondrion (GO:1903146)regulation of cellular response to oxidative stress (GO:1900407)regulation of hydrogen peroxide metabolic process (GO:0010310)regulation of mitochondrial membrane potential (GO:0051881)regulation of mitochondrial membrane potential (GO:0051881)regulation of mitochondrion organization (GO:0010821)regulation of neuron apoptotic process (GO:0043523)regulation of oxidative phosphorylation (GO:0002082)regulation of proteasomal protein catabolic process (GO:0061136)regulation of protein localization to mitochondrion (GO:1903747)regulation of protein localization to mitochondrion (GO:1903747)regulation of protein ubiquitination (GO:0031396)regulation of protein ubiquitination (GO:0031396)regulation of protein-containing complex assembly (GO:0043254)regulation of reactive oxygen species metabolic process (GO:2000377)regulation of reactive oxygen species metabolic process (GO:2000377)regulation of synaptic vesicle transport (GO:1902803)respiratory electron transport chain (GO:0022904)response to ischemia (GO:0002931)response to oxidative stress (GO:0006979)response to stress (GO:0006950)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process (GO:0006511)

Expression (TPM)

TFs regulating PINK1 0 TFs

Transcription factors with Perturb-seq knockdown data for PINK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PINK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PINK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PINK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr1:20,342,875–20,344,326	289.8 kb	Distal (>10kb) Multiome	261
	chr1:20,366,975–20,367,437	266.2 kb	Distal (>10kb) Multiome	164
	chr1:20,402,741–20,403,363	230.5 kb	Distal (>10kb) Multiome	165
	chr1:20,430,474–20,430,904	202.8 kb	Distal (>10kb) Multiome	217
	chr1:20,485,233–20,485,959	147.8 kb	Distal (>10kb) Multiome	348
	chr1:20,486,131–20,487,438	146.6 kb	Distal (>10kb) Multiome	760
	chr1:20,493,822–20,494,241	139.4 kb	Distal (>10kb) Multiome	430
	chr1:20,507,717–20,508,432	125.3 kb	Distal (>10kb) Multiome	811
	chr1:20,552,019–20,553,890	81.1 kb	Distal (>10kb) Multiome	518
	chr1:20,588,675–20,590,358	44.5 kb	Distal (>10kb) Multiome	431
	chr1:20,625,186–20,625,881	8.0 kb	Proximal (<10kb) Multiome	123
	chr1:20,633,024–20,634,989	389 bp	At TSS Multiome	759
	chr1:20,661,099–20,662,130	28.1 kb	Distal (>10kb) Multiome	784
	chr1:20,696,319–20,697,384	63.4 kb	Distal (>10kb) Multiome	727
	chr1:20,717,384–20,718,370	84.4 kb	Distal (>10kb) Multiome	440
	chr1:20,731,726–20,733,330	98.8 kb	Distal (>10kb) Multiome	718
	chr1:20,786,021–20,787,857	153.5 kb	Distal (>10kb) Multiome	963

Genome Browser

Genomic view of the PINK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.