Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for PIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,538,339–9,539,009 | 296.6 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 252.8 kb | Distal (>10kb) Multiome | 99 | |
| chr19:9,584,055–9,584,863 | 250.7 kb | Distal (>10kb) Multiome | 801 | |
| chr19:9,620,792–9,622,027 | 214.0 kb | Distal (>10kb) Multiome | 856 | |
| chr19:9,674,791–9,675,456 | 160.2 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 66.6 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 49.5 kb | Distal (>10kb) Multiome | 727 | |
| chr19:9,791,515–9,793,483 | 42.5 kb | Distal (>10kb) Multiome | 507 | |
| chr19:9,818,302–9,820,113 | 16.0 kb | Distal (>10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 7.5 kb | Proximal (<10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 208 bp | At TSS Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 78.4 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 79.5 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 99.0 kb | Distal (>10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 101.2 kb | Distal (>10kb) Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 192.5 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 251.0 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 260.9 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 271.0 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 277.9 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 284.6 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the PIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.