The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for PIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:36,874,493–36,875,198 | 295.3 kb | Distal (>10kb) Multiome | 1007 | |
| chr6:36,885,507–36,886,260 | 284.3 kb | Distal (>10kb) Multiome | 1011 | |
| chr6:36,985,740–36,986,913 | 183.8 kb | Distal (>10kb) Multiome | 926 | |
| chr6:37,051,534–37,052,487 | 118.4 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr6:37,059,338–37,060,100 | 110.5 kb | Distal (>10kb) Multiome HiCAR | 824 | |
| chr6:37,071,640–37,072,385 | 98.3 kb | Distal (>10kb) Multiome HiCAR | 281 | |
| chr6:37,102,284–37,103,074 | 67.5 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr6:37,125,557–37,126,783 | 44.1 kb | Distal (>10kb) Multiome | 528 | |
| chr6:37,137,028–37,138,409 | 32.4 kb | Distal (>10kb) Multiome | 735 | |
| chr6:37,141,368–37,141,988 | 28.4 kb | Distal (>10kb) Multiome | 239 | |
| chr6:37,168,853–37,171,673 | 199 bp | At TSS Multiome | 1096 | |
| chr6:37,172,048–37,172,496 | 2.2 kb | Proximal (<10kb) Multiome | 818 | |
| chr6:37,221,712–37,222,953 | 52.5 kb | Distal (>10kb) Multiome | 747 | |
| chr6:37,257,338–37,258,482 | 87.6 kb | Distal (>10kb) Multiome | 890 | |
| chr6:37,319,150–37,319,973 | 149.4 kb | Distal (>10kb) Multiome | 54 | |
| chr6:37,353,783–37,354,458 | 183.9 kb | Distal (>10kb) Multiome | 794 | |
| chr6:37,432,813–37,433,740 | 263.1 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the PIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.