Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including early endosome to late endosome transport; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Located in ciliary basal body; intercellular bridge; and late endosome. Part of phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PIK3R4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3R4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3R4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:130,746,370–130,747,018 | 12 bp | At TSS Multiome | 579 | |
| chr3:130,789,260–130,790,422 | 43.2 kb | Distal (>10kb) Multiome | 205 | |
| chr3:130,892,988–130,894,828 | 147.2 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr3:131,026,288–131,027,342 | 280.0 kb | Distal (>10kb) Multiome | 772 |
Genomic view of the PIK3R4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.