This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIGC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:172,278,274–172,278,975 | 165.4 kb | Distal (>10kb) Multiome | 172 | |
| chr1:172,360,503–172,361,306 | 83.4 kb | Distal (>10kb) Multiome | 314 | |
| chr1:172,443,641–172,444,611 | 45 bp | At TSS Multiome | 880 | |
| chr1:172,449,593–172,450,576 | 5.5 kb | Proximal (<10kb) | 568 | |
| chr1:172,531,992–172,534,273 | 88.8 kb | Distal (>10kb) Multiome | 997 | |
| chr1:172,544,331–172,545,606 | 100.9 kb | Distal (>10kb) Multiome | 138 | |
| chr1:172,559,459–172,560,699 | 115.9 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the PIGC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.