This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIGB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:55,196,449–55,197,580 | 122.2 kb | Distal (>10kb) Multiome | 812 | |
| chr15:55,288,999–55,291,001 | 28.7 kb | Distal (>10kb) Multiome | 744 | |
| chr15:55,318,855–55,319,494 | 27 bp | At TSS Multiome | 875 | |
| chr15:55,394,084–55,395,667 | 75.8 kb | Distal (>10kb) Multiome | 153 | |
| chr15:55,407,568–55,409,007 | 89.1 kb | Distal (>10kb) Multiome | 957 | |
| chr15:55,498,088–55,498,593 | 179.2 kb | Distal (>10kb) Multiome | 637 | |
| chr15:55,587,537–55,588,889 | 269.1 kb | Distal (>10kb) Multiome | 432 |
Genomic view of the PIGB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.