The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for PIEZO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIEZO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIEZO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,533,022–88,535,493 | 251.1 kb | Distal (>10kb) Multiome | 458 | |
| chr16:88,569,589–88,571,104 | 214.9 kb | Distal (>10kb) Multiome | 904 | |
| chr16:88,634,178–88,635,155 | 150.6 kb | Distal (>10kb) Multiome | 384 | |
| chr16:88,650,385–88,651,684 | 134.1 kb | Distal (>10kb) Multiome | 890 | |
| chr16:88,662,399–88,664,138 | 122.0 kb | Distal (>10kb) Multiome | 943 | |
| chr16:88,686,082–88,687,017 | 98.7 kb | Distal (>10kb) Multiome | 675 | |
| chr16:88,705,859–88,706,820 | 78.8 kb | Distal (>10kb) Multiome | 838 | |
| chr16:88,737,237–88,737,815 | 47.7 kb | Distal (>10kb) Multiome | 619 | |
| chr16:88,769,688–88,770,137 | 15.4 kb | Distal (>10kb) Multiome | 282 | |
| chr16:88,770,700–88,771,325 | 14.1 kb | Distal (>10kb) Multiome | 668 | |
| chr16:88,784,542–88,785,880 | 161 bp | At TSS Multiome | 811 | |
| chr16:88,802,766–88,805,068 | 18.5 kb | Distal (>10kb) Multiome | 881 | |
| chr16:88,810,968–88,812,892 | 26.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr16:88,856,080–88,858,003 | 71.8 kb | Distal (>10kb) Multiome | 885 | |
| chr16:88,940,964–88,942,110 | 156.7 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the PIEZO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.