The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for PIDD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIDD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIDD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:506,153–507,989 | 302.3 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 273.8 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 272.0 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 254.3 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 248.7 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 240.9 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 233.4 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 195.8 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 193.6 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 172.4 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 114.1 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 103.4 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 88.6 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 81.3 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 62.2 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 46.2 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 32.1 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 25.8 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 11.2 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 4.2 kb | Proximal (<10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 230 bp | At TSS Multiome | 976 | |
| chr11:818,369–820,592 | 10.1 kb | Distal (>10kb) Multiome | 749 | |
| chr11:826,980–828,116 | 18.0 kb | Distal (>10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 20.9 kb | Distal (>10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 23.4 kb | Distal (>10kb) Multiome | 562 | |
| chr11:842,034–843,556 | 33.2 kb | Distal (>10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 35.0 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 40.3 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 101.5 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 116.4 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the PIDD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.