The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PICK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PICK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PICK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,802,124–37,802,989 | 254.8 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 252.0 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 249.4 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 239.3 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 232.2 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 212.8 kb | Distal (>10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 207.8 kb | Distal (>10kb) Multiome | 753 | |
| chr22:37,905,849–37,906,846 | 150.9 kb | Distal (>10kb) Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 123.1 kb | Distal (>10kb) Multiome | 679 | |
| chr22:37,953,153–37,954,120 | 103.5 kb | Distal (>10kb) Multiome | 617 | |
| chr22:37,983,021–37,985,110 | 72.8 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 4.7 kb | Proximal (<10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 105 bp | At TSS Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 23.9 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 40.8 kb | Distal (>10kb) Multiome | 186 | |
| chr22:38,181,365–38,182,291 | 124.7 kb | Distal (>10kb) Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 144.7 kb | Distal (>10kb) Multiome | 848 | |
| chr22:38,214,397–38,215,017 | 157.6 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 215.8 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 260.2 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 262.4 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 279.1 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 296.3 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,569,664–38,571,256 | 513.2 kb | Distal (>10kb) Multiome HiCAR | 559 |
Genomic view of the PICK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.