PIAS4
protein inhibitor of activated STAT 4 | FLJ12419, PIASY, Piasg, ZMIZ6

Enables SUMO ligase activity and ubiquitin protein ligase binding activity. Involved in negative regulation of protein localization to chromatin; protein sumoylation; and regulation of primary metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6
Biological processes 49 terms
DNA binding (GO:0003677)PML body (GO:0016605)SUMO ligase activity (GO:0061665)SUMO ligase activity (GO:0061665)SUMO ligase activity (GO:0061665)SUMO transferase activity (GO:0019789)SUMO transferase activity (GO:0019789)SUMO transferase activity (GO:0019789)SUMO transferase activity (GO:0019789)chromatin (GO:0000785)cytoplasm (GO:0005737)double-strand break repair (GO:0006302)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of protein localization to chromatin (GO:0120186)negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426)nuclear matrix (GO:0016363)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of double-strand break repair via homologous recombination (GO:1905168)positive regulation of keratinocyte apoptotic process (GO:1902174)positive regulation of keratinocyte apoptotic process (GO:1902174)positive regulation of protein sumoylation (GO:0033235)protein binding (GO:0005515)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)regulation of cellular response to stress (GO:0080135)regulation of gene expression (GO:0010468)regulation of mRNA stability (GO:0043488)regulation of transcription by RNA polymerase II (GO:0006357)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription regulator inhibitor activity (GO:0140416)transferase complex (GO:1990234)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)vitamin D metabolic process (GO:0042359)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)
Expression (TPM)
PIAS4 — as a Regulated Gene

TFs regulating PIAS4 0 TFs

Transcription factors with Perturb-seq knockdown data for PIAS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIAS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PIAS4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIAS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:3,721,462–3,721,997 286.1 kb Distal (>10kb) Multiome 760
chr19:3,722,652–3,723,093 284.8 kb Distal (>10kb) Multiome 106
chr19:3,761,103–3,762,150 246.2 kb Distal (>10kb) Multiome 839
chr19:3,762,300–3,763,344 244.8 kb Distal (>10kb) Multiome 817
chr19:3,786,012–3,786,456 221.6 kb Distal (>10kb) Multiome 237
chr19:3,868,451–3,869,181 138.8 kb Distal (>10kb) Multiome 233
chr19:3,932,937–3,933,664 74.5 kb Distal (>10kb) Multiome 198
chr19:3,968,623–3,969,280 38.9 kb Distal (>10kb) Multiome 547
chr19:3,970,535–3,971,713 36.5 kb Distal (>10kb) Multiome 728
chr19:3,985,032–3,985,862 22.3 kb Distal (>10kb) Multiome 932
chr19:3,987,682–3,988,217 19.7 kb Distal (>10kb) Multiome 346
chr19:4,006,992–4,008,553 197 bp At TSS Multiome 888
chr19:4,064,058–4,067,782 58.2 kb Distal (>10kb) Multiome 811
chr19:4,123,681–4,124,581 116.4 kb Distal (>10kb) Multiome 798
chr19:4,182,102–4,182,890 174.8 kb Distal (>10kb) Multiome 862
chr19:4,198,066–4,198,600 190.6 kb Distal (>10kb) Multiome 214
chr19:4,246,623–4,247,617 239.5 kb Distal (>10kb) Multiome 960

Genome Browser

Genomic view of the PIAS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:3,711,462 – 4,257,617
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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