PIAS2

protein inhibitor of activated STAT 2 | ARIP3, PIASX-ALPHA, PIASX-BETA, ZMIZ4, miz

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

Member of: DE-3 DE-3.25

Biological processes 35 terms

DNA binding (GO:0003677)PML body (GO:0016605)PML body (GO:0016605)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)SMAD protein signal transduction (GO:0060395)SUMO ligase activity (GO:0061665)SUMO ligase activity (GO:0061665)SUMO transferase activity (GO:0019789)SUMO transferase activity (GO:0019789)chromatin (GO:0000785)endoplasmic reticulum unfolded protein response (GO:0030968)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of androgen receptor signaling pathway (GO:0060766)negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)regulation of transcription by RNA polymerase II (GO:0006357)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription regulator inhibitor activity (GO:0140416)transforming growth factor beta receptor signaling pathway (GO:0007179)ubiquitin protein ligase binding (GO:0031625)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating PIAS2 0 TFs

Transcription factors with Perturb-seq knockdown data for PIAS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIAS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PIAS2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIAS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr18:46,657,856–46,658,572	259.1 kb	Distal (>10kb) Multiome	342
chr18:46,756,207–46,757,254	160.6 kb	Distal (>10kb) Multiome	210
chr18:46,916,768–46,918,244	36 bp	At TSS Multiome	715
chr18:46,946,455–46,947,310	29.4 kb	Distal (>10kb) Multiome	249
chr18:47,149,543–47,151,037	232.9 kb	Distal (>10kb) Multiome	824
chr18:47,175,919–47,176,532	258.8 kb	Distal (>10kb) Multiome	731

Genome Browser

Genomic view of the PIAS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.