PIAS1

PIAS1

protein inhibitor of activated STAT 1 | GBP, GU/RH-II, ZMIZ3, DDXBP1

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Member of: DE-3 DE-3.1

Biological processes 64 terms

DNA damage response (GO:0006974)DNA-binding transcription factor binding (GO:0140297)G1/S transition of mitotic cell cycle (GO:0000082)PML body (GO:0016605)PML body (GO:0016605)PML body (GO:0016605)SUMO ligase activity (GO:0061665)SUMO ligase activity (GO:0061665)SUMO ligase activity (GO:0061665)SUMO transferase activity (GO:0019789)SUMO transferase activity (GO:0019789)SUMO transferase activity (GO:0019789)cell surface receptor signaling pathway via JAK-STAT (GO:0007259)chromatin (GO:0000785)cytoskeleton (GO:0005856)enzyme binding (GO:0019899)fat cell differentiation (GO:0045444)glutamatergic synapse (GO:0098978)negative regulation of apoptotic process (GO:0043066)negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426)negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear periphery (GO:0034399)nuclear periphery (GO:0034399)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein localization to cell periphery (GO:1904377)positive regulation of protein sumoylation (GO:0033235)positive regulation of protein sumoylation (GO:0033235)positive regulation of smooth muscle cell differentiation (GO:0051152)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)postsynaptic cytosol (GO:0099524)presynaptic cytosol (GO:0099523)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein-DNA complex assembly (GO:0065004)regulation of cell population proliferation (GO:0042127)regulation of cell population proliferation (GO:0042127)spermatogenesis (GO:0007283)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription regulator inhibitor activity (GO:0140416)transcription regulator inhibitor activity (GO:0140416)ubiquitin protein ligase binding (GO:0031625)visual learning (GO:0008542)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating PIAS1 0 TFs

Transcription factors with Perturb-seq knockdown data for PIAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PIAS1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr15:67,782,016–67,782,994	272.1 kb	Distal (>10kb) Multiome	131
	chr15:67,825,208–67,826,124	228.8 kb	Distal (>10kb) Multiome	173
	chr15:67,839,939–67,840,842	214.0 kb	Distal (>10kb) Multiome HiCAR	902
	chr15:67,863,421–67,864,037	190.6 kb	Distal (>10kb) Multiome HiCAR	767
	chr15:67,884,552–67,885,084	169.5 kb	Distal (>10kb) Multiome	754
	chr15:67,967,988–67,968,440	86.1 kb	Distal (>10kb) Multiome	234
	chr15:68,053,850–68,055,256	14 bp	At TSS Multiome	832
	chr15:68,229,045–68,230,269	175.4 kb	Distal (>10kb) Multiome	889
	chr15:68,256,694–68,257,399	202.8 kb	Distal (>10kb) Multiome	551
	chr15:68,277,201–68,278,718	223.6 kb	Distal (>10kb) Multiome	1100

Genome Browser

Genomic view of the PIAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.