Enables 2-oxoglutarate-dependent dioxygenase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHYHD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHYHD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHYHD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,656,436–128,657,126 | 265.4 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:128,683,393–128,684,010 | 238.6 kb | Distal (>10kb) Multiome | 296 | |
| chr9:128,688,449–128,689,713 | 233.2 kb | Distal (>10kb) Multiome | 805 | |
| chr9:128,723,691–128,725,229 | 198.1 kb | Distal (>10kb) Multiome | 821 | |
| chr9:128,771,658–128,772,301 | 150.3 kb | Distal (>10kb) Multiome | 940 | |
| chr9:128,786,928–128,787,516 | 135.1 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 103.8 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 92.4 kb | Distal (>10kb) Multiome HiCAR | 782 | |
| chr9:128,881,863–128,882,454 | 40.2 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | at TSS | At TSS | 378 | |
| chr9:128,947,329–128,947,815 | 25.3 kb | Distal (>10kb) Multiome | 865 | |
| chr9:129,027,821–129,028,677 | 106.1 kb | Distal (>10kb) Multiome | 639 | |
| chr9:129,036,276–129,036,937 | 114.2 kb | Distal (>10kb) Multiome | 736 | |
| chr9:129,080,488–129,081,502 | 158.7 kb | Distal (>10kb) Multiome | 755 | |
| chr9:129,110,314–129,111,708 | 188.7 kb | Distal (>10kb) Multiome | 881 | |
| chr9:129,177,207–129,178,809 | 256.0 kb | Distal (>10kb) Multiome | 824 | |
| chr9:129,208,459–129,208,914 | 286.5 kb | Distal (>10kb) Multiome | 108 |
Genomic view of the PHYHD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.