This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PHACTR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHACTR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHACTR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:28,088,113–28,088,897 | 281.0 kb | Distal (>10kb) Multiome | 827 | |
| chr1:28,104,959–28,105,483 | 264.5 kb | Distal (>10kb) Multiome | 240 | |
| chr1:28,232,593–28,233,160 | 136.7 kb | Distal (>10kb) Multiome | 666 | |
| chr1:28,235,692–28,236,588 | 133.7 kb | Distal (>10kb) Multiome | 862 | |
| chr1:28,247,126–28,247,685 | 122.4 kb | Distal (>10kb) Multiome | 544 | |
| chr1:28,258,840–28,260,822 | 109.3 kb | Distal (>10kb) Multiome | 910 | |
| chr1:28,369,387–28,370,499 | 43 bp | At TSS Multiome | 961 | |
| chr1:28,505,412–28,506,885 | 136.2 kb | Distal (>10kb) Multiome | 969 | |
| chr1:28,513,136–28,516,505 | 145.8 kb | Distal (>10kb) Multiome | 461 | |
| chr1:28,517,302–28,519,364 | 148.6 kb | Distal (>10kb) Multiome | 927 | |
| chr1:28,552,370–28,553,806 | 183.2 kb | Distal (>10kb) Multiome | 955 | |
| chr1:28,580,985–28,582,501 | 212.1 kb | Distal (>10kb) Multiome | 1080 | |
| chr1:28,592,018–28,592,768 | 222.7 kb | Distal (>10kb) Multiome | 394 | |
| chr1:28,642,403–28,643,726 | 273.4 kb | Distal (>10kb) Multiome | 980 | |
| chr1:28,648,003–28,650,002 | 279.1 kb | Distal (>10kb) Multiome | 1377 | |
| chr1:28,667,742–28,669,783 | 298.7 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the PHACTR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.