Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity and calcium ion binding activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in endoplasmic reticulum. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PGS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,127,361–78,129,338 | 249.9 kb | Distal (>10kb) Multiome | 909 | |
| chr17:78,140,136–78,141,130 | 238.1 kb | Distal (>10kb) Multiome | 594 | |
| chr17:78,168,117–78,169,078 | 210.1 kb | Distal (>10kb) Multiome | 738 | |
| chr17:78,186,463–78,187,739 | 191.4 kb | Distal (>10kb) Multiome | 1021 | |
| chr17:78,213,978–78,214,702 | 164.4 kb | Distal (>10kb) Multiome | 902 | |
| chr17:78,231,715–78,232,315 | 146.6 kb | Distal (>10kb) Multiome | 147 | |
| chr17:78,250,689–78,251,651 | 127.6 kb | Distal (>10kb) Multiome | 714 | |
| chr17:78,254,178–78,254,892 | 124.1 kb | Distal (>10kb) Multiome | 860 | |
| chr17:78,270,255–78,273,257 | 106.2 kb | Distal (>10kb) Multiome | 667 | |
| chr17:78,278,089–78,278,902 | 100.1 kb | Distal (>10kb) Multiome | 225 | |
| chr17:78,313,762–78,314,579 | 64.4 kb | Distal (>10kb) Multiome | 636 | |
| chr17:78,341,604–78,342,374 | 36.6 kb | Distal (>10kb) Multiome | 423 | |
| chr17:78,351,461–78,352,240 | 26.9 kb | Distal (>10kb) Multiome | 383 | |
| chr17:78,352,598–78,353,774 | 25.5 kb | Distal (>10kb) Multiome | 687 | |
| chr17:78,356,201–78,356,710 | 22.2 kb | Distal (>10kb) Multiome | 319 | |
| chr17:78,358,869–78,361,525 | 18.4 kb | Distal (>10kb) Multiome | 898 | |
| chr17:78,365,478–78,366,101 | 12.8 kb | Distal (>10kb) Multiome | 305 | |
| chr17:78,374,737–78,374,964 | 3.7 kb | Proximal (<10kb) | 126 | |
| chr17:78,378,324–78,379,091 | 45 bp | At TSS Multiome | 921 | |
| chr17:78,381,668–78,382,108 | 3.0 kb | Proximal (<10kb) | 187 |
Genomic view of the PGS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.