Enables glucose-1,6-bisphosphate synthase activity. Predicted to be involved in glucose metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PGM2L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGM2L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGM2L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:74,170,498–74,171,610 | 227.3 kb | Distal (>10kb) Multiome | 881 | |
| chr11:74,311,252–74,311,993 | 86.8 kb | Distal (>10kb) Multiome | 289 | |
| chr11:74,388,761–74,388,942 | 9.5 kb | Proximal (<10kb) | 140 | |
| chr11:74,397,487–74,397,688 | 744 bp | At TSS | 163 | |
| chr11:74,397,796–74,399,222 | 220 bp | At TSS Multiome | 811 | |
| chr11:74,467,393–74,467,865 | 69.0 kb | Distal (>10kb) Multiome | 174 | |
| chr11:74,492,667–74,494,411 | 95.0 kb | Distal (>10kb) Multiome | 897 | |
| chr11:74,592,212–74,593,000 | 194.2 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the PGM2L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.