Enables glycosyltransferase activity. Involved in GPI anchor biosynthetic process. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PGAP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGAP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGAP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:101,397,915–101,399,348 | 88.4 kb | Distal (>10kb) Multiome | 861 | |
| chr9:101,449,087–101,449,796 | 37.8 kb | Distal (>10kb) Multiome | 494 | |
| chr9:101,458,960–101,459,540 | 27.9 kb | Distal (>10kb) Multiome | 253 | |
| chr9:101,460,651–101,461,628 | 26.0 kb | Distal (>10kb) Multiome | 103 | |
| chr9:101,485,920–101,487,719 | 114 bp | At TSS Multiome | 692 | |
| chr9:101,533,168–101,534,447 | 46.6 kb | Distal (>10kb) Multiome | 723 | |
| chr9:101,737,499–101,739,011 | 251.2 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the PGAP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.