PGAM1
phosphoglycerate mutase 1 | PGAM-B, PGAMA

The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Member of: DE-1
Biological processes 28 terms
bisphosphoglycerate mutase activity (GO:0004082)bisphosphoglycerate mutase activity (GO:0004082)canonical glycolysis (GO:0061621)canonical glycolysis (GO:0061621)canonical glycolysis (GO:0061621)catalytic activity (GO:0003824)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)gluconeogenesis (GO:0006094)gluconeogenesis (GO:0006094)glycolytic process (GO:0006096)intramolecular phosphotransferase activity (GO:0016868)membrane (GO:0016020)phosphoglycerate mutase activity (GO:0004619)phosphoglycerate mutase activity (GO:0004619)phosphoglycerate mutase activity (GO:0004619)phosphoglycerate mutase activity (GO:0004619)phosphoglycerate mutase activity (GO:0004619)phosphoglycerate mutase activity (GO:0004619)protein binding (GO:0005515)protein kinase binding (GO:0019901)secretory granule lumen (GO:0034774)
Expression (TPM)
PGAM1 — as a Regulated Gene

TFs regulating PGAM1 0 TFs

Transcription factors with Perturb-seq knockdown data for PGAM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGAM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PGAM1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGAM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr10:97,179,559–97,180,186 246.2 kb Distal (>10kb) Multiome 190
chr10:97,185,462–97,186,037 240.3 kb Distal (>10kb) Multiome 248
chr10:97,195,967–97,196,850 229.7 kb Distal (>10kb) Multiome 469
chr10:97,291,972–97,293,103 133.5 kb Distal (>10kb) Multiome 945
chr10:97,318,840–97,320,386 107.0 kb Distal (>10kb) Multiome 836
chr10:97,333,472–97,335,742 91.2 kb Distal (>10kb) Multiome 917
chr10:97,336,929–97,337,706 88.9 kb Distal (>10kb) Multiome 362
chr10:97,400,817–97,401,691 24.9 kb Distal (>10kb) Multiome 644
chr10:97,407,246–97,407,739 18.7 kb Distal (>10kb) Multiome 539
chr10:97,418,830–97,419,461 7.1 kb Proximal (<10kb) Multiome 323
chr10:97,425,050–97,426,796 64 bp At TSS Multiome 715
chr10:97,427,521–97,428,103 1.3 kb Proximal (<10kb) 333
chr10:97,445,521–97,446,585 20.0 kb Distal (>10kb) Multiome 802
chr10:97,497,718–97,499,773 72.5 kb Distal (>10kb) Multiome 967
chr10:97,553,598–97,554,047 127.6 kb Distal (>10kb) Multiome 340
chr10:97,632,775–97,633,915 207.3 kb Distal (>10kb) Multiome 725
chr10:97,640,236–97,641,335 214.4 kb Distal (>10kb) Multiome 712
chr10:97,686,724–97,687,987 261.2 kb Distal (>10kb) Multiome 993
chr10:97,713,223–97,715,263 287.6 kb Distal (>10kb) Multiome 639

Genome Browser

Genomic view of the PGAM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr10:97,169,559 – 97,725,263
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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