This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for PEX26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEX26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEX26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:17,921,809–17,922,254 | 155.8 kb | Distal (>10kb) Multiome | 99 | |
| chr22:17,960,960–17,961,542 | 116.7 kb | Distal (>10kb) Multiome | 44 | |
| chr22:18,000,452–18,002,000 | 76.4 kb | Distal (>10kb) Multiome | 878 | |
| chr22:18,023,594–18,024,038 | 54.3 kb | Distal (>10kb) Multiome | 438 | |
| chr22:18,076,145–18,076,342 | 1.6 kb | Proximal (<10kb) | 236 | |
| chr22:18,077,594–18,078,615 | 22 bp | At TSS Multiome | 711 | |
| chr22:18,149,651–18,150,235 | 71.9 kb | Distal (>10kb) Multiome | 573 |
Genomic view of the PEX26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.