This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for PEX19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEX19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEX19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,031,268–160,032,381 | 253.2 kb | Distal (>10kb) Multiome | 780 | |
| chr1:160,046,290–160,047,082 | 238.5 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 214.7 kb | Distal (>10kb) Multiome | 419 | |
| chr1:160,083,809–160,084,575 | 200.9 kb | Distal (>10kb) Multiome | 327 | |
| chr1:160,095,707–160,096,231 | 189.1 kb | Distal (>10kb) Multiome | 79 | |
| chr1:160,097,214–160,099,572 | 186.3 kb | Distal (>10kb) Multiome | 659 | |
| chr1:160,100,845–160,101,543 | 184.0 kb | Distal (>10kb) Multiome HiCAR | 530 | |
| chr1:160,169,049–160,170,141 | 115.4 kb | Distal (>10kb) Multiome | 330 | |
| chr1:160,192,913–160,193,769 | 91.9 kb | Distal (>10kb) Multiome | 551 | |
| chr1:160,204,860–160,206,035 | 79.7 kb | Distal (>10kb) Multiome | 637 | |
| chr1:160,261,515–160,263,143 | 22.7 kb | Distal (>10kb) Multiome | 992 | |
| chr1:160,284,609–160,285,332 | 18 bp | At TSS Multiome | 638 | |
| chr1:160,291,386–160,291,589 | 6.2 kb | Proximal (<10kb) | 189 | |
| chr1:160,342,945–160,343,700 | 58.2 kb | Distal (>10kb) Multiome | 868 | |
| chr1:160,399,764–160,401,441 | 115.3 kb | Distal (>10kb) Multiome | 590 | |
| chr1:160,539,925–160,540,644 | 255.1 kb | Distal (>10kb) Multiome | 479 |
Genomic view of the PEX19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.