This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PEX14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEX14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEX14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:10,209,800–10,211,585 | 264.6 kb | Distal (>10kb) Multiome | 934 | |
| chr1:10,398,334–10,400,006 | 76.0 kb | Distal (>10kb) Multiome | 1064 | |
| chr1:10,430,062–10,431,244 | 44.4 kb | Distal (>10kb) Multiome | 1007 | |
| chr1:10,472,017–10,472,900 | 2.5 kb | Proximal (<10kb) Multiome | 872 | |
| chr1:10,474,760–10,475,474 | 22 bp | At TSS Multiome | 744 | |
| chr1:10,638,357–10,639,497 | 164.2 kb | Distal (>10kb) Multiome | 126 | |
| chr1:10,679,481–10,679,929 | 204.8 kb | Distal (>10kb) Multiome | 463 | |
| chr1:10,693,857–10,695,287 | 219.8 kb | Distal (>10kb) Multiome | 382 | |
| chr1:10,704,382–10,704,894 | 229.7 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the PEX14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.