Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Implicated in mitochondrial complex IV deficiency nuclear type 19. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PET117. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PET117 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PET117, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:17,938,730–17,940,231 | 198.7 kb | Distal (>10kb) Multiome | 678 | |
| chr20:17,968,085–17,969,639 | 169.0 kb | Distal (>10kb) Multiome | 1144 | |
| chr20:18,032,971–18,033,755 | 104.7 kb | Distal (>10kb) Multiome | 212 | |
| chr20:18,057,257–18,058,052 | 80.0 kb | Distal (>10kb) Multiome | 323 | |
| chr20:18,058,764–18,059,467 | 78.7 kb | Distal (>10kb) Multiome | 393 | |
| chr20:18,101,249–18,101,961 | 36.2 kb | Distal (>10kb) Multiome | 74 | |
| chr20:18,103,190–18,103,994 | 34.2 kb | Distal (>10kb) Multiome | 149 | |
| chr20:18,137,127–18,138,367 | 20 bp | At TSS Multiome | 1046 | |
| chr20:18,144,520–18,145,374 | 6.7 kb | Proximal (<10kb) | 259 | |
| chr20:18,287,674–18,288,982 | 150.5 kb | Distal (>10kb) Multiome | 971 | |
| chr20:18,413,071–18,413,534 | 275.5 kb | Distal (>10kb) Multiome | 167 |
Genomic view of the PET117 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.