Involved in positive regulation of neutrophil chemotaxis and positive regulation of proteolysis. Predicted to be located in desmosome and plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PERP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PERP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PERP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:137,866,196–137,868,323 | 240.3 kb | Distal (>10kb) Multiome | 1107 | |
| chr6:138,008,459–138,009,355 | 98.4 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr6:138,086,433–138,087,221 | 20.7 kb | Distal (>10kb) Multiome | 571 | |
| chr6:138,102,083–138,102,263 | 5.2 kb | Proximal (<10kb) | 21 | |
| chr6:138,105,499–138,106,672 | 1.2 kb | Proximal (<10kb) Multiome | 557 | |
| chr6:138,106,898–138,108,486 | 178 bp | At TSS Multiome | 878 | |
| chr6:138,109,320–138,109,670 | 1.9 kb | Proximal (<10kb) | 196 | |
| chr6:138,115,982–138,116,178 | 8.6 kb | Proximal (<10kb) | 253 | |
| chr6:138,160,942–138,162,612 | 54.5 kb | Distal (>10kb) Multiome | 699 | |
| chr6:138,240,458–138,241,750 | 133.8 kb | Distal (>10kb) Multiome | 180 | |
| chr6:138,331,206–138,332,418 | 224.3 kb | Distal (>10kb) Multiome | 260 | |
| chr6:138,403,215–138,405,244 | 296.8 kb | Distal (>10kb) Multiome HiCAR | 1060 |
Genomic view of the PERP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.