This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PELO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PELO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PELO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:52,786,801–52,788,836 | 183 bp | At TSS Multiome | 833 | |
| chr5:52,797,515–52,798,334 | 9.6 kb | Proximal (<10kb) | 36 | |
| chr5:52,799,077–52,801,097 | 12.2 kb | Distal (>10kb) Multiome | 910 | |
| chr5:52,988,570–52,990,478 | 201.4 kb | Distal (>10kb) Multiome | 746 |
Genomic view of the PELO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.