Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for PEDS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEDS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEDS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:49,915,234–49,916,043 | 238.1 kb | Distal (>10kb) Multiome | 965 | |
| chr20:49,936,000–49,936,835 | 217.4 kb | Distal (>10kb) Multiome | 878 | |
| chr20:49,979,039–49,979,667 | 174.4 kb | Distal (>10kb) Multiome | 832 | |
| chr20:49,982,091–49,984,748 | 170.9 kb | Distal (>10kb) Multiome | 1116 | |
| chr20:49,997,468–49,998,291 | 156.0 kb | Distal (>10kb) Multiome | 80 | |
| chr20:50,012,403–50,013,184 | 140.9 kb | Distal (>10kb) Multiome | 334 | |
| chr20:50,112,672–50,113,319 | 40.6 kb | Distal (>10kb) Multiome | 839 | |
| chr20:50,153,404–50,154,338 | 90 bp | At TSS Multiome | 1028 | |
| chr20:50,165,812–50,166,377 | 12.4 kb | Distal (>10kb) Multiome | 1037 | |
| chr20:50,171,676–50,172,948 | 18.7 kb | Distal (>10kb) Multiome | 821 | |
| chr20:50,189,686–50,192,514 | 36.8 kb | Distal (>10kb) Multiome | 1125 | |
| chr20:50,194,979–50,195,626 | 41.7 kb | Distal (>10kb) Multiome | 299 | |
| chr20:50,321,165–50,321,654 | 167.8 kb | Distal (>10kb) Multiome | 683 |
Genomic view of the PEDS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.